656 Mouse anti-human CD42b (Platelet GPIb) monoclonal antibody, clone VM16d 1 ml

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Article Number: 656

Monoclonal antibody anti-human CD42b (Platelet GPIb) (clone VM16d, IgG1 kappa fraction)


The monoclonal antibody is directed against the CD42b antigen, platelet glycoprotein GPIb, that serves as a receptor for von Willebrand factor and as a high affinity thrombin receptor. The antigen is expressed on human platelets and megakaryocytes. The antigen is absent or present in very low levels on platelets of patients with the Bernard-Soulier syndrome. VM16d inhibits low conc. thrombin (<0.1 U/ml) induced platelet aggregation and decreases thrombin binding to platelets. F(ab')2 and F(ab') fragments are equally effective as whole intact antibodies. the VM16d-epitope is located within the 45 kDa N-terminal domain of GPIb alpha- chain. VM16d does not effect platelet interaction with von Willebrand factor, leading to the conclusion that the antibody reacts with or nearby the thrombin receptor site


Ammonium sulphate precipitation and DEAE-cellulose chromatography with gradient elution


Purified and lyophilized. Contains azide and PBS. The azide concentration in reconstituted solution is 3 mM


Analysis of platelet aggregation and detection of GPIb expression. The antibody is also useful for functional studies


Use 1 ml sterile pure water


Shipping at ambient temperature. Storage of lyophilized antibodies 2 years at -20°C or lower


Qi Y et al. Novel antibodies against GPIb alpha inhibit pulmonary metastasis by affecting vWF-GPIb alpha interaction. Corpus ID: 108285710